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CBD oil side effects

CBD oil side effects

CBD is a chemical that naturally occurs in the cannabis plant and can be derived from it. CBD is a cannabinoid and occurs naturally in both the human body as well as the cannabis plant.

 

It has antioxidant, anti-inflammatory, neuroprotective, and anti-convulsant properties. CBD is a very strong neuroprotective antioxidant.

 

It has even shown to be effective in treating cancer cells in vitro. It’s hypothesized that if taken in higher doses the cannabinoid may prove to be remedial for various psychiatric disorders such as schizophrenia and dementia.

 

Research for other diseases such as diabetes and nausea is underway.

 

Safety regarding the use of CBD

Cannabis is identified as safe for use. In respect to toxicity, research shows that substances like alcohol and nicotine are way more dangerous than cannabis.

 

The major risk connected to cannabis use is that of mental illness. The psychoactive compound THC is related to causing any mental distress in its consumers.

 

However, CBD is derived from cannabis plants that are exclusively bred for a high content of CBD and it only contains a trace amount of THC. CBD is non-psychoactive and hence safe for use.

 

CBD acts on the CB1 and CB2 receptors of the endocannabinoid system of our body indirectly. It also interacts with other receptors present in our body.

 

CBD has shown to have some side effects too. While they are not so serious, one should be aware of the effects of anything they might be putting in their bodies.

 

Studies and Reviews on the side effects of CBD

 

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/, this review was published in 2017 in the journal Cannabis and Cannabinoid Research. It delves into the safety and side effects of CBD.
    • There were various studies done on the use of CBD, mainly on psychotic disorders and epilepsy. The most frequent side effects identified were changes in weight and appetite, tiredness, and diarrhea.
    • It can be perceived through this review that CBD has a better side effect profile when compared to the other drugs being used for treating the same medical conditions.
  • https://www.ncbi.nlm.nih.gov/pubmed/22129319, this review published in the journal Current Drug Safety, shows that CBD has no adverse effects on physiological parameters such as heart rate, blood pressure, body temperature, psychological and psychomotor functions, gastrointestinal transit, and food intake.
    • The side effects concerning CBD have mostly been observed in vitro and in animal studies.
    • The side effects include altering cell viability, reduced fertilization capacity, and inhibiting liver drug metabolism.
    • Trials on humans are required to understand the side effects CBD can have on the human body.
  • https://www.tandfonline.com/doi/abs/10.3109/00207458608985678, Published in 2009 in the International Journal of Neuroscience, this study was conducted on patients with dystonic movement disorders.
    • CBD was administered in the range of 100–600mg per day for 6 weeks along with standard medications.
    • Movement disorders were observed to have improved in all patients.
    • A few side effects were observed including low blood pressure, dry mouth, psychomotor slowing, lightheadedness, and sedation.
    • A dose of over 300mg per day increased hypokinesia and resting tremor. This has led researchers to believe that CBD may aggravate Parkinson’s in humans.
  • https://www.ncbi.nlm.nih.gov/pubmed/25237116 is a study published in 2014 in the Journal of Psychopharmacology which determined that CBD can help improve the quality of life in people suffering from Parkinson’s disease.

 

Other common CBD side effects

  • Liver drug metabolism
    • CBD can affect how our liver metabolizes drugs as it interacts with enzymes that are responsible for metabolizing drugs, for example, the cytochrome P450 family.
    • CYP3A4 is the enzyme responsible for metabolizing CBD. If you are taking certain pharmaceutical drugs than they can inhibit CYP3A4 which can result in the slow breakdown of CBD and increase its physiological activity.
    • Some drugs can even increase the level of CYP3A4 that can cause CBD to breakdown faster than normal. So, if you plan on consuming CBD and are taking any pharmaceutical drugs, you should consult your physician regarding it.
  • Dry mouth

If your method of consumption is smoking then you might feel like there is a cotton ball in your mouth. Consume plentiful liquids to avoid this sensation.

Cannabis can decrease the secretion of saliva hence the feeling of dry mouth.

  • Sedation

This might help with insomnia or relief from other symptoms like pain or discomfort.

  • GI tract issues
    • CBD can affect the gastrointestinal (GI) tract. It usually occurs due to the carrier oil being used.
    • The side effects may include diarrhea, nausea, vomiting, and dizziness.
  • Mental health side effects

Side effects on mental health are more common if consuming oils which have higher levels of THC. The side effects may include anxiety, depression or in extreme cases even psychosis.

  • Low Blood Pressure.
  • Change in Appetite
    • Cannabis can make people feel hungrier but oftentimes it has also shown to have suppressed the appetite of the consumer. This can be attributed to the concentration of CBD and THC in the oil being used.
    • While CBD suppresses the appetite, THC boosts it.
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